A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates.

ABSTRACT:

Background

Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylation have been extensively studied in mouse and human, their conservation in other vertebrates remains poorly explored. In this study, we interrogated the distribution and function of DNA methylation in primary fibroblasts of seven vertebrate species including bio-medical models and livestock species (human, mouse, rabbit, dog, cow, pig, and chicken).

Results

Our data highlight both divergence and conservation of DNA methylation patterns and functions. We show that the chicken genome is hypomethylated compared to other vertebrates. Furthermore, compared to mouse, other species show a higher frequency of methylation of CpG-rich D

SUBMITTER: Al Adhami H 

PROVIDER: S-EPMC8941758 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature