Larrea divaricata: anti-inflammatory and antioxidant effects of on macrophages and low density lipoproteins.

ABSTRACT:

Background

The oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and to atherosclerosis. Plants are a source of effective and innocuous antioxidants. Larrea divaricata Cav. (Zygophyllaceae) is used in Argentina folk medicine for its anti-inflammatory properties.

Methods

The aim of this work was to study the antioxidant and anti-inflammatory effects of the aqueous extract (AE) of L. divaricata on macrophages under glucose stimulation and on human LDL and HDL particles under free radical generators.

Results

AE reduced the lipid peroxidation (17%), nitric oxide (NO) (47-50%), tumor necrosis factor-α (TNF-α) (32%) and free

SUBMITTER: Peralta I 

PROVIDER: S-EPMC8941816 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature