Glycosylation is key for enhancing drug recognition into spike glycoprotein of SARS-CoV-2.

ABSTRACT: The emergence of COVID-19 caused by SARS-CoV-2 and its spread since 2019 represents the major public health problem worldwide nowadays, which has generated a high number of infections and deaths. The spike protein (S protein) is the most studied protein of SARS-CoV-2, and key to host-cell entry through ACE2 receptor. This protein presents a large pattern of glycosylations with important roles in immunity and infection mechanisms. Therefore, understanding key aspects of the molecular mechanisms of these structures, during drug recognition in SARS-CoV-2, may contribute to therapeutic alternatives. In this work, we explored the impact of glycosylations on the drug recognition on two domains of the S protein, the receptor-binding domain (RBD) and the N-terminal domain (NTD) through molecular d

SUBMITTER: Ropon-Palacios G 

PROVIDER: S-EPMC8941845 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature