Perturbation of Alphavirus and Flavivirus Infectivity by Components of the Bacterial Cell Wall.

ABSTRACT: The impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inoculation is the biting site in the host skin, which is colonized by a complex microbial community that could possibly influence arbovirus infection. We demonstrated that preincubation of arboviruses with certain components of the bacterial cell wall, including lipopolysaccharides (LPS) of some Gram-negative bacteria and lipoteichoic acids or peptidoglycan of certain Gram-positive bacteria, significantly reduced arbovirus infectivity in vitro. This inhibitory effect was observed for arboviruses of different virus families, including chikungunya virus o

SUBMITTER: Langendries L 

PROVIDER: S-EPMC8941878 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature