Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice.

ABSTRACT: Recent evidence indicates that viral components of the microbiota can contribute to intestinal homeostasis and protection from local inflammatory or infectious insults. However, host-derived mechanisms that regulate the virome remain largely unknown. In this study, we used colonization with the model commensal murine norovirus (MNV; strain CR6) to interrogate host-directed mechanisms of viral regulation, and we show that STAT1 is a central coordinator of both viral replication and antiviral T cell responses. In addition to restricting CR6 replication to the intestinal tract, we show that STAT1 regulates antiviral CD4⁺ and CD8⁺ T cell responses and prevents systemic viral-induced tissue damage and disease. Despite altered T cell responses that resemble those that media

SUBMITTER: Sharon AJ 

PROVIDER: S-EPMC8941907 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature