N-acetylcysteine in non-acetaminophen-induced acute liver failure: a systematic review and meta-analysis of prospective studies.

ABSTRACT:

Introduction

There are discordant reports on N-acetylcysteine (NAC) efficacy in non-acetaminophen acute liver failure (ALF).

Aim

To determine whether NAC is beneficial in non-acetaminophen ALF.

Material and methods

We performed a systemic review and meta-analysis of published data to address the question. PubMed and MEDLINE were searched using the terms non-acetylcysteine and ALF due to non-acetaminophen, viral infection, drug-induced or autoimmune hepatitis. The primary outcome was overall mortality. Secondary outcomes were transplant-free survival and length of hospital stay. Risk ratios were calculated using a random model for meta-analysis.

Results

A total of 672 patients were included in this meta-analysis from 5 prospective studies (NAC group: n =

SUBMITTER: Amjad W 

PROVIDER: S-EPMC8942009 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature