Identification of novel, cryptic Clostridioides species isolates from environmental samples collected from diverse geographical locations.

ABSTRACT: Clostridioides difficile is a pathogen often associated with hospital-acquired infection or antimicrobial-induced disease; however, increasing evidence indicates infections can result from community or environmental sources. Most genomic sequencing of C. difficile has focused on clinical strains, although evidence is growing that C. difficile spores are widespread in soil and water in the environment. In this study, we sequenced 38 genomes collected from soil and water isolates in Flagstaff (AZ, USA) and Slovenia in an effort targeted towards environmental surveillance of C. difficile. At the average nucleotide identity (ANI) level, the genomes were divergent to C. difficile at a threshold consistent with different species. A phylogenetic analysis of thes

SUBMITTER: Williamson CHD 

PROVIDER: S-EPMC8942030 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature