Development of 2-deoxystreptamine-nucleobase conjugates for the inhibition of oncogenic miRNA production.

ABSTRACT: The discovery of new original scaffolds for selective RNA targeting is one of the main challenges of current medicinal chemistry since therapeutically relevant RNAs represent potential targets for a number of pathologies. Recent efforts have been devoted to the search for RNA ligands targeting the biogenesis of oncogenic miRNAs whose overexpression has been directly linked to the development of various cancers. In this work, we developed a new series of RNA ligands for the targeting of oncogenic miRNA biogenesis based on the 2-deoxystreptamine scaffold. The latter is part of the aminoglycoside neomycin and is known to play an essential role in the RNA interaction of this class of RNA binders. 2-deoxystreptamine was thus conjugated to natural and artificial nucleobases to obtain new binders

SUBMITTER: Tran TPA 

PROVIDER: S-EPMC8942232 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature