Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analogues.

ABSTRACT: Based on the molecular hybridization strategy, thirty-four imidazo[1,2-a]pyridine amides (IPAs) and imidazo[1,2-a]pyridine sulfonamides (IPSs) were designed and synthesized. The structures of the target compounds were characterized using ¹H NMR, ¹³C NMR, LCMS, and elemental analyses. The synthesized compounds were evaluated in vitro for anti-tubercular activity using the microplate Alamar Blue assay against Mycobacterium tuberculosis H37Rv strain and the MIC was determined. The evaluated compounds exhibited MIC in the range 0.05-≤100 μg mL^-1. Among these derivatives, IPA-6 (MIC 0.05 μg mL^-1), IPA-9 (MIC 0.4 μg mL^-1), and IPS-1 (MIC 0.4 μg mL^-1) displayed excellent anti-TB acti

SUBMITTER: Khetmalis YM 

PROVIDER: S-EPMC8942254 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature