CALCRL Gene is a Suitable Prognostic Factor in AML/ETO⁺ AML Patients.

ABSTRACT:

Introduction

The t(8 ; 21) translocation is the most common chromosomal abnormality in human acute myeloid leukemia (AML) subtype 2 (M2), which forms the AML/ETO fusion gene. However, AML/ETO alone does not necessarily cause leukemia. Other factors are thought to contribute to the disease. Calcitonin receptor-like (CALCRL), a G-protein-coupled neuropeptide receptor, is involved in various biological processes, such as colony formation and drug resistance.

Methods

First, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to determine any differences in CALCRL expression in AML patients with and without AML/ETO and the prognostic significance of CALCRL expression in AML patients was further evaluated. Next, we detected the CAL

SUBMITTER: Wang R 

PROVIDER: S-EPMC8942673 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature