Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression.

ABSTRACT: The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression. Herein, we undertook a novel approach to address the role of gastric ECM in tumorigenesis, which remained largely unexplored. By combining decellularization techniques with a high-throughput quantitative proteomics approach, we have performed an extensive characterization of human gastric mucosa, uncovering its composition and distribution among tumor, normal adjacent and normal distant mucosa. Our results revealed a common ECM signature composed of 142 proteins and indicated that gastric carcinogenesis encompasses ECM remodeling through alterations in the abundance of 24 components, mainly base

SUBMITTER: Moreira AM 

PROVIDER: S-EPMC8942767 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature