OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα_z.

ABSTRACT: Heterotrimeric G proteins are the main signalling effectors for G protein-coupled receptors. Understanding the distinct functions of different G proteins is key to understanding how their signalling modulates physiological responses. Pertussis toxin, a bacterial AB₅ toxin, inhibits Gα_i/o G proteins and has proven useful for interrogating inhibitory G protein signalling. Pertussis toxin, however, does not inhibit one member of the inhibitory G protein family, Gα_z. The role of Gα_z signalling has been neglected largely due to a lack of inhibitors. Recently, the identification of another Pertussis-like AB₅ toxin was described. Here we show that this toxin, that we call OZITX, specifically inhibits Gα_i/o and Gα_z G prot

SUBMITTER: Keen AC 

PROVIDER: S-EPMC8943041 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature