No obesity paradox in patients with community-acquired pneumonia - secondary analysis of a randomized controlled trial.

ABSTRACT:

Background

Obesity is associated with an increased risk for several chronic conditions and mortality. However, there are data in support of beneficial outcome in acute medical conditions such as community-acquired pneumonia (CAP), termed "obesity paradox". The aim of this study was to test the association of BMI with clinical outcomes in a large randomized clinical trial of patients hospitalized with CAP.

Design and methods

In total, 773 patients hospitalized with CAP were included in this study. Patients were stratified into four groups according to their baseline BMI (underweight <18.5, normal weight 18.5-25, overweight 25-30, and obese >30 kg/m²). The primary endpoint was time to clinical stability (TTCS). Secondary endpoints included 30-day mortality, ICU admi

SUBMITTER: Borisov AN 

PROVIDER: S-EPMC8943130 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature