Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice.

ABSTRACT: The lymphatic vasculature is critical for lung function, but defects in lymphatic function in the pathogenesis of lung disease is understudied. In mice, lymphatic dysfunction alone is sufficient to cause lung injury that resembles human emphysema. Whether lymphatic function is disrupted in cigarette smoke (CS)-induced emphysema is unknown. In this study, we investigated the effect of CS on lung lymphatic function. Analysis of human lung tissue revealed significant lung lymphatic thrombosis in patients with emphysema compared to control smokers that increased with disease severity. In a mouse model, CS exposure led to lung lymphatic thrombosis, decreased lymphatic drainage, and impaired leukocyte trafficking that all preceded the development of emphysema. Proteomic analysis demonstrated an

SUBMITTER: Summers BD 

PROVIDER: S-EPMC8943143 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature