Local induction of regulatory T cells prevents inflammatory bone loss in ligature-induced experimental periodontitis in mice.

ABSTRACT: Periodontitis (periodontal disease) is a highly prevalent disease, affecting over 65 million adults in the United States alone. Characterized by an overburden of invasive bacteria, gum inflammation and plaque buildup, over time, these symptoms can result in severe loss of gingival tissue attachment, bone resorption and even tooth loss. Although current treatments (local antibiotics and scaling and root planing procedures) target the bacterial dysbiosis, they do not address the underlying inflammatory imbalance in the periodontium. In the healthy steady state, the body naturally combats destructive, imbalanced inflammatory responses through regulatory pathways mediated by cells such as regulatory T cells (Tregs). Consequently, we hypothesized that local enrichment of regulatory lymphocytes

SUBMITTER: Greene AC 

PROVIDER: S-EPMC8943171 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature