Outstanding prognostic value of novel ferroptosis-related genes in chemoresistance osteosarcoma patients.

ABSTRACT: Osteosarcoma (OS) is the most common bone-derived tumor, and chemoresistance is a pivotal factor in the poor prognosis of patients with OS. Ferroptosis, as an emerging modality of regulated cell death, has demonstrated potential value in tumor chemoresistance studies. Through the gene expression omnibus database in conjunction with the FerrDb database, we identified novel ferroptosis-related differentially expressed genes (DEGs) involving chemoresistance in OS patients. Subsequently, enrichment analysis, protein-protein interaction network analysis and survival analysis were performed sequentially to recognize the hub genes and ultimately to construct a predictive model. The model constructed from the TARGET database was exhibited in a nomogram and assessed by calibration curves. The progn

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8943205 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature