Mucosal cryobiopsies: a new method for studying airway pathology in asthma.

ABSTRACT: In vivo studies of airway pathology in obstructive lung disease are limited by poor quality of specimens obtained with forceps. Obtainment of cryobiopsies has increased diagnostic yield in cancer and interstitial lung disease but has not been used in patients with asthma. In a recent pilot study, we found mucosal cryobiopsies to be larger and more intact than conventional forceps biopsies. The aim of the present study was to compare quality and safety of mucosal cryobiopsies versus conventional forceps biopsies in patients with asthma. Endobronchial biopsies were obtained with forceps and cryoprobe from patients with asthma not currently treated with inhaled steroids and evaluated histologically. A total of 240 cryobiopsies and 288 forceps biopsies were obtained from 48 patients. Bleeding

SUBMITTER: Hvidtfeldt M 

PROVIDER: S-EPMC8943287 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature