Immunomodulatory activity of ethanol extract of Annona reticulata L. leaf in cultured immune cells and in Swiss albino mice.

ABSTRACT:

Background

Annona reticulata Linn, has been shown to possess antipyretic, antihelmintic, hypoglycemic, antiulcer and wound healing properties. However, its immunomodulatory role is yet to be explored.

Objective(s)

In the present study, we intended to investigate the effects of A. reticulata leaf ethanol extract on various components of the immune system.

Material and methods

The effects of A. reticulata leaf extract on human peripheral blood mononuclear cells, monocyte (THP1), and human macrophage (U937) cell lines were investigated. An animal study was conducted to observe the effect of the extract on humoral as well as cell mediated immunity.

Results

The extract stimulated proliferation of human PBMC, monocytes (THP1), and macrophages (U937) significantly in

SUBMITTER: Mazumdar S 

PROVIDER: S-EPMC8943405 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature