Vitamin B12 (Cobalamin) Deficiency in Overt and Subclinical Primary Hypothyroidism.

ABSTRACT:

Background

B12 (cobalamin) deficiency has been reported in hypothyroid patients with variable prevalence rates thus routine screening of hypothyroid patients was recommended by some and discouraged by others. We aimed to assess the prevalence of B12 deficiency among hypothyroid patients and to evaluate for pernicious anemia and celiac disease as etiologies.

Methods

A total 133 patients were included. Thyroid hormones and thyroid peroxidase (TPO) autoantibodies were measured. Serum B12 was measured and if deficient, intrinsic factor antibodies (IFAB) and tissue transglutaminase (tTG) antibodies were evaluated.

Results

Our study included 45 patients with overt hypothyroidism (OH), 48 patients with subclinical hypothyroidism (SCH), and 40 patients as controls. Mean age w

SUBMITTER: Aon M 

PROVIDER: S-EPMC8943463 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature