Novel imaging phenotypes of naive asthma patients with distinctive clinical characteristics and T2 inflammation traits.

ABSTRACT:

Objective

This study aims to describe the imaging features of naïve asthma patients, defined as not receiving corticosteroids or other asthma medications for at least 1 month, and their association with therapeutic response, and to discover novel unbiased imaging phenotypes.

Methods

A total of 109 naïve asthma patients and 50 healthy controls were enrolled in this study. Clinical data and imaging indices of high-resolution computed tomography were collected. The correlation between imaging indices and clinical features was analyzed. Cluster analyses were adopted to determine three novel imaging phenotypes.

Results

Compared with healthy controls, naïve asthma patients presented higher scores of airway remodeling, bronchiectasis, and mucus plugs. Mean airway wall area (

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8943467 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature