Feedback-controlled dynamics of neuronal cells on directional surfaces.

ABSTRACT: The formation of neuronal networks is a complex phenomenon of fundamental importance for understanding the development of the nervous system. The basic process underlying the network formation is axonal growth, a process involving the extension of axons from the cell body and axonal navigation toward target neurons. Axonal growth is guided by the interactions between the tip of the axon (growth cone) and its extracellular environmental cues, which include intercellular interactions, the biochemical landscape around the neuron, and the mechanical and geometrical features of the growth substrate. Here, we present a comprehensive experimental and theoretical analysis of axonal growth for neurons cultured on micropatterned polydimethylsiloxane (PDMS) surfaces. We demonstrate that closed-loop f

SUBMITTER: Descoteaux M 

PROVIDER: S-EPMC8943704 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature