Therapeutic hypothermia for neonatal encephalopathy with sepsis: a retrospective cohort study.

ABSTRACT:

Objective

Neonatal encephalopathy remains a major cause of infant mortality and neurodevelopmental impairment. Infection may exacerbate brain injury and mitigate the effect of therapeutic hypothermia (TH). Additionally, infants with sepsis treated with TH may be at increased risk of adverse effects. This study aimed to review the clinical characteristics and outcomes for infants with sepsis treated with TH.

Design and setting

Retrospective cohort study of infants treated with TH within Australia and New Zealand.

Patients

1522 infants treated with TH, including 38 with culture-positive sepsis from 2014 to 2018.

Intervention

Anonymised retrospective review of data from Australian and New Zealand Neonatal Network. Infants with culture-positive sepsis within 48 hou

SUBMITTER: Sibbin K 

PROVIDER: S-EPMC8943717 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature