A mathematical analysis of focal adhesion lifetimes and their effect on cell motility.

ABSTRACT: By analyzing the distributions of focal adhesion (FA) lifetimes from different cell types, we found that a gamma distribution best matched the experimental distributions. In all but one case, it was a unimodal, non-symmetric gamma distribution. We used a mathematical model of cell motion to help understand the mechanics and data behind the FA lifetime distributions. The model uses a detach-rate function to determine how long an FA will persist before it detaches. The detach-rate function that produced distributions with a best-fit gamma curve that closely matched that of the data was both force and time dependent. Using the data gathered from the matching simulations, we calculated both the cell speed and mean FA lifetime and compared them. Where available, we also compared this relationsh

SUBMITTER: Rosen ME 

PROVIDER: S-EPMC8943753 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature