Ontology highlight
ABSTRACT:
SUBMITTER: Katt WP
PROVIDER: S-EPMC8943831 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Katt William P WP Aplin Cody C Cerione Richard A RA
OncoTargets and therapy 20220319
Tissue transglutaminase (tTG) is a rather unique GTP-binding/protein crosslinking enzyme that has been shown to play important roles in a number of cellular processes that impact both normal physiology and disease states. This is especially the case in the context of aggressive brain tumors, such as glioblastoma. The diverse roles played by tTG in cancer survival and progression have led to significant interest in recent years in using tTG as a therapeutic target. In this review, we provide a br ...[more]