Rapid 'on-column' preparation of hydrogen [¹¹C]cyanide from [¹¹C]methyl iodide via [¹¹C]formaldehyde.

ABSTRACT: Hydrogen [¹¹C]cyanide ([¹¹C]HCN) is a versatile ¹¹C-labelling agent for the production of ¹¹C-labelled compounds used for positron emission tomography (PET). However, the traditional method for [¹¹C]HCN production requires a dedicated infrastructure, limiting accessibility to [¹¹C]HCN. Herein, we report a simple and efficient [¹¹C]HCN production method that can be easily implemented in ¹¹C production facilities. The immediate production of [¹¹C]HCN was achieved by passing gaseous [¹¹C]methyl iodide ([¹¹C]CH₃I) through a small two-layered reaction column. The first layer contained an N-oxide and a sulfoxide for conversion of [¹¹C]CH₃

SUBMITTER: Kikuchi T 

PROVIDER: S-EPMC8943838 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature