Brain region networks for the assimilation of new associative memory into a schema.

ABSTRACT: Alterations in long-range functional connectivity between distinct brain regions are thought to contribute to the encoding of memory. However, little is known about how the activation of an existing network of neocortical and hippocampal regions might support the assimilation of relevant new information into the preexisting knowledge structure or 'schema'. Using functional mapping for expression of plasticity-related immediate early gene products, we sought to identify the long-range functional network of paired-associate memory, and the encoding and assimilation of relevant new paired-associates. Correlational and clustering analyses for expression of immediate early gene products revealed that midline neocortical-hippocampal connectivity is strongly associated with successful memory enco

SUBMITTER: Takeuchi T 

PROVIDER: S-EPMC8943948 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature