Genetic characterization of atypical porcine pestivirus from neonatal piglets with congenital tremor in Hubei province, China.

ABSTRACT:

Background

Atypical porcine pestivirus (APPV) is a single-stranded RNA virus with high genetic variation that causes congenital tremor (CT) in newborn piglets, belonging to the genus Pestivirus of the family Flaviviridae. Increasing cases of APPV infection in China in the past few years would pose severe challenges to the development of pig production. In view of the high genetic variability of APPV, the genetic characteristics of APPV in Hubei province was determined.

Methods

52 tissue samples from 8 CT-affected newborn piglets were collected at two different periods in the same pig farm in Hubei province. Viral nucleic acid was extracted to detect pathogens that can cause CT in piglets or other common clinical pathogens by RT-PCR. Haematoxylin and eosin (HE) staining, immu

SUBMITTER: Ren X 

PROVIDER: S-EPMC8944037 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature