Exosomal CagA from Helicobacter pylori aggravates intestinal epithelium barrier dysfunction in chronic colitis by facilitating Claudin-2 expression.

ABSTRACT:

Background

The chronic infection with Helicobacter pylori (H. pylori), especially cytotoxin-associated gene A-positive (CagA⁺) strains, has been associated with various extragastric disorders. Evaluating the potential impacts of virulence factor CagA on intestine may provide a better understanding of H. pylori pathogenesis such as colitis. The intestinal mucosal barrier is essential for maintaining its integrity and functions. However, how persistent CagA⁺ H. pylori colonization influences barrier disruption and thereby affects chronic colitis is not fully understood.

Results

Chronic colitis models of CagA⁺ H. pylori-colonized mice treated with 2% Dextran sulphate sodium (DSS) were established to assess the disease activity and pertinent expr

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8944046 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature