The relationships between women's reproductive factors: a Mendelian randomisation analysis.

ABSTRACT:

Background

Women's reproductive factors include their age at menarche and menopause, the age at which they start and stop having children and the number of children they have. Studies that have linked these factors with disease risk have largely investigated individual reproductive factors and have not considered the genetic correlation and total interplay that may occur between them. This study aimed to investigate the nature of the relationships between eight female reproductive factors.

Methods

We used data from the UK Biobank and genetic consortia with data available for the following reproductive factors: age at menarche, age at menopause, age at first birth, age at last birth, number of births, being parous, age first had sexual intercourse and lifetime number of sexua

SUBMITTER: Prince C 

PROVIDER: S-EPMC8944090 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature