CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer.

ABSTRACT:

Background

Cancer is caused by a combination of genetic and epigenetic abnormalities. Current cancer therapies are limited due to the complexity of their mechanism, underlining the need for alternative therapeutic approaches. Interestingly, combining the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) system with next-generation sequencing (NGS) has the potential to speed up the identification, validation, and targeting of high-value targets.

Main text

Personalized or precision medicine combines genetic information with phenotypic and environmental characteristics to produce healthcare tailored to the individual and eliminates the constraints of "one-size-fits-all" therapy. Precision medicine is now possible thanks to cancer genome sequencing. Having

SUBMITTER: Selvakumar SC 

PROVIDER: S-EPMC8944095 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature