Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels.

ABSTRACT:

Background

Extracellular vesicles (EVs) are released by nearly every cell type and have attracted much attention for their ability to transfer protein and diverse RNA species from donor to recipient cells. Much attention has been given so far to the features of EV short RNAs such as miRNAs. However, while the presence of mRNA and long noncoding RNA (lncRNA) transcripts in EVs has also been reported by multiple different groups, the properties and function of these longer transcripts have been less thoroughly explored than EV miRNA. Additionally, the impact of EV export on the transcriptome of exporting cells has remained almost completely unexamined. Here, we globally investigate mRNA and lncRNA transcripts in endothelial EVs in multiple different conditions.

Results

In basa

SUBMITTER: O'Grady T 

PROVIDER: S-EPMC8944098 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature