Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study.

ABSTRACT:

Background & aims

Antiepileptic drugs (AEDs) are a common cause of drug-induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other than seizures. Contemporaneous data related to trends and characteristics of AED-related liver injury are sparse.

Methods

We report the trends, characteristics, and outcomes of patients with AED-related DILI enrolled into the DILIN Prospective Study between 2004 and 2020.

Results

Among 1,711 participants with definite, highly likely, or probable DILI, 66 (3.9%) had AED-related DILI (lamotrigine [n = 18], phenytoin [n = 16], carbamazepine [n = 11], valproate [n = 10], gabapentin [n = 4], and others [n = 7]). The frequ

SUBMITTER: Chalasani N 

PROVIDER: S-EPMC8944173 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature