Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC8944923 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Li Hongjie H Janssens Jasper J De Waegeneer Maxime M Kolluru Sai Saroja SS Davie Kristofer K Gardeux Vincent V Saelens Wouter W David Fabrice P A FPA Brbić Maria M Spanier Katina K Leskovec Jure J McLaughlin Colleen N CN Xie Qijing Q Jones Robert C RC Brueckner Katja K Shim Jiwon J Tattikota Sudhir Gopal SG Schnorrer Frank F Rust Katja K Nystul Todd G TG Carvalho-Santos Zita Z Ribeiro Carlos C Pal Soumitra S Mahadevaraju Sharvani S Przytycka Teresa M TM Allen Aaron M AM Goodwin Stephen F SF Berry Cameron W CW Fuller Margaret T MT White-Cooper Helen H Matunis Erika L EL DiNardo Stephen S Galenza Anthony A O'Brien Lucy Erin LE Dow Julian A T JAT Jasper Heinrich H Oliver Brian B Perrimon Norbert N Deplancke Bart B Quake Stephen R SR Luo Liqun L Aerts Stein S Agarwal Devika D Ahmed-Braimah Yasir Y Arbeitman Michelle M Ariss Majd M MM Augsburger Jordan J Ayush Kumar K Baker Catherine C CC Banisch Torsten T Birker Katja K Bodmer Rolf R Bolival Benjamin B Brantley Susanna E SE Brill Julie A JA Brown Nora C NC Buehner Norene A NA Cai Xiaoyu Tracy XT Cardoso-Figueiredo Rita R Casares Fernando F Chang Amy A Clandinin Thomas R TR Crasta Sheela S Desplan Claude C Detweiler Angela M AM Dhakan Darshan B DB Donà Erika E Engert Stefanie S Floc'hlay Swann S George Nancy N González-Segarra Amanda J AJ Groves Andrew K AK Gumbin Samantha S Guo Yanmeng Y Harris Devon E DE Heifetz Yael Y Holtz Stephen L SL Horns Felix F Hudry Bruno B Hung Ruei-Jiun RJ Jan Yuh Nung YN Jaszczak Jacob S JS Jefferis Gregory S X E GSXE Karkanias Jim J Karr Timothy L TL Katheder Nadja Sandra NS Kezos James J Kim Anna A AA Kim Seung K SK Kockel Lutz L Konstantinides Nikolaos N Kornberg Thomas B TB Krause Henry M HM Labott Andrew Thomas AT Laturney Meghan M Lehmann Ruth R Leinwand Sarah S Li Jiefu J Li Joshua Shing Shun JSS Li Kai K Li Ke K Li Liying L Li Tun T Litovchenko Maria M Liu Han-Hsuan HH Liu Yifang Y Lu Tzu-Chiao TC Manning Jonathan J Mase Anjeli A Matera-Vatnick Mikaela M Matias Neuza Reis NR McDonough-Goldstein Caitlin E CE McGeever Aaron A McLachlan Alex D AD Moreno-Roman Paola P Neff Norma N Neville Megan M Ngo Sang S Nielsen Tanja T O'Brien Caitlin E CE Osumi-Sutherland David D Özel Mehmet Neset MN Papatheodorou Irene I Petkovic Maja M Pilgrim Clare C Pisco Angela Oliveira AO Reisenman Carolina C Sanders Erin Nicole EN Dos Santos Gilberto G Scott Kristin K Sherlekar Aparna A Shiu Philip P Sims David D Sit Rene V RV Slaidina Maija M Smith Harold E HE Sterne Gabriella G Su Yu-Han YH Sutton Daniel D Tamayo Marco M Tan Michelle M Tastekin Ibrahim I Treiber Christoph C Vacek David D Vogler Georg G Waddell Scott S Wang Wanpeng W Wilson Rachel I RI Wolfner Mariana F MF Wong Yiu-Cheung E YE Xie Anthony A Xu Jun J Yamamoto Shinya S Yan Jia J Yao Zepeng Z Yoda Kazuki K Zhu Ruijun R Zinzen Robert P RP
Science (New York, N.Y.) 20220304 6584
For more than 100 years, the fruit fly <i>Drosophila melanogaster</i> has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula <i>Drosophilae</i>, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whol ...[more]
