Prognosis Value of Immunoregulatory Molecules in Oral Cancer Microenvironment: An Immunohistochemical Study.

ABSTRACT: To evaluate the relationship of the immune-checkpoint PD-1/PD-L1 with the clinical evolution of OSCC; to assess survival in OSCC based on the characteristics of TME and histologic risk score; to evaluate the clinical and histopathological relationship of OSCC with immunological TME. A retrospective study was carried out on 65 samples from patients with OSCC on the floor of the mouth or tongue. Clinicopathological variables and the expression of the biomarkers PD-1, PD-L1, FoxP3, CD4, CD8, CSF1R, and p16 were recorded. The relationship of the clinical and histological variables with the expression of the biomarkers and survival was studied. The univariate and multivariate analysis indicated that positive PD-1 expression was an independent protective factor for survival (overall, disease-fre

SUBMITTER: Pena-Cardelles JF 

PROVIDER: S-EPMC8945047 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature