Reduced cardiovascular morbidity in patients with hemophilia: results of a 5-year multinational prospective study.

ABSTRACT: Hemophilia is a congenital bleeding disorder caused by low levels of clotting factor VIII or IX. The life expectancy of people with hemophilia (PWH) has increased with the availability of clotting factor concentrates. At the same time, the incidence of cardiovascular disease (CVD) has increased; in retrospective studies, there are conflicting data regarding if, despite this increase, the incidence is still lower than in the general population. We prospectively compared the incidence of CVD in PWH vs the predicted incidence. This prospective, multicenter, observational study included adult PWH (aged >30 years) from The Netherlands and United Kingdom. They were followed up for a 5-year period, and CVD incidence was compared with a predicted event rate based on the QRISK2-2011 CVD risk model.

SUBMITTER: Van Der Valk P 

PROVIDER: S-EPMC8945305 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature