Cardiac Calcifications: Phenotypes, Mechanisms, Clinical and Prognostic Implications.

ABSTRACT: There is a growing interest in arterial and heart valve calcifications, as these contribute to cardiovascular outcome, and are leading predictors of cardiovascular and kidney diseases. Cardiovascular calcifications are often considered as one disease, but, in effect, they represent multifaced disorders, occurring in different milieus and biological phenotypes, following different pathways. Herein, we explore each different molecular process, its relative link with the specific clinical condition, and the current therapeutic approaches to counteract calcifications. Thus, first, we explore the peculiarities between vascular and valvular calcium deposition, as this occurs in different tissues, responds differently to shear stress, has specific etiology and time courses to calcification. Then,

SUBMITTER: Vieceli Dalla Sega F 

PROVIDER: S-EPMC8945469 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature