CCL5 Deficiency Enhanced Cryo-Thermal-Triggered Long-Term Anti-Tumor Immunity in 4T1 Murine Breast Cancer.

ABSTRACT: Breast cancer remains one of the most common solid tumors. Tumor immunosuppressive factors mainly hinder the control of tumors. We previously developed an innovative cryo-thermal therapy that was shown to significantly suppress distal metastasis and improve long-term survival in murine B16F10 melanoma and 4T1 mammary carcinoma models. However, the effect of cryo-thermal therapy on the 4T1 model was not excellent. CCL5 has been reported to help the progression of breast cancer, so in this study, CCL5-/- was used to explore the role of host-derived CCL5 after cryo-thermal therapy. CCL5-/- could not completely resist tumor development, but it significantly improved survival rates when combined with cryo-thermal therapy. Mechanically, CCL5-/- mildly decreases the percentage of MDSCs, increases

SUBMITTER: Lou Y 

PROVIDER: S-EPMC8945488 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature