Multiparameter phenotyping of platelet reactivity for stratification of human cohorts.

ABSTRACT: Accurate and comprehensive assessment of platelet function across cohorts of donors may be key to understanding the risk of thrombotic events associated with cardiovascular disease, and, hence, to help personalize the application of antiplatelet drugs. However, platelet function tests can be difficult to perform and analyze; they also can be unreliable or uninformative and poorly standardized across studies. The Platelet Phenomic Analysis (PPAnalysis) assay and associated open-source software platform were developed in response to these challenges. PPAnalysis utilizes preprepared freeze-dried microtiter plates to provide a detailed characterization of platelet function. The automated analysis of the high-dimensional data enables the identification of subpopulations of donors with distinct

SUBMITTER: Dunster JL 

PROVIDER: S-EPMC8945618 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature