Deciphering Tumour Heterogeneity: From Tissue to Liquid Biopsy.

ABSTRACT: Human solid malignancies harbour a heterogeneous set of cells with distinct genotypes and phenotypes. This heterogeneity is installed at multiple levels. A biological diversity is commonly observed between tumours from different patients (inter-tumour heterogeneity) and cannot be fully captured by the current consensus molecular classifications for specific cancers. To extend the complexity in cancer, there are substantial differences from cell to cell within an individual tumour (intra-tumour heterogeneity, ITH) and the features of cancer cells evolve in space and time. Currently, treatment-decision making usually relies on the molecular characteristics of a limited tumour tissue sample at the time of diagnosis or disease progression but does not take into account the complexity of the bu

SUBMITTER: Gilson P 

PROVIDER: S-EPMC8946040 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature