Worry Modifies the Relationship between Locus Coeruleus Activity and Emotional Mnemonic Discrimination.

ABSTRACT: The locus coeruleus (LC) plays a critical role in modulating emotional memory performance via widespread connections to the medial temporal lobe (MTL). Interestingly, both the LC and MTL are affected during aging. Therefore, we aimed to investigate whether worry during cognitive aging changes the relationship between memory performance and the neural activity patterns during an emotional memory task. Twenty-eight participants aged 60-83 years from the Maastricht Aging study conducted an emotional mnemonic discrimination task during a 7T fMRI-scan. We performed a robust multiple linear regression to examine the association between worry and mnemonic memory performance under different levels of arousal. Subsequently, we examined if worry modifies the relationship between neuronal activity an

SUBMITTER: Pagen LHG 

PROVIDER: S-EPMC8946181 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature