MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity.

ABSTRACT: To successfully generate distant metastases, metastatic progenitor cells must simultaneously possess mesenchymal characteristics, resist to anoïkis, migrate and invade directionally, resist to redox and shear stresses in the systemic circulation, and possess stem cell characteristics. These cells primarily originate from metabolically hostile areas of the primary tumor, where oxygen and nutrient deprivation, together with metabolic waste accumulation, exert a strong selection pressure promoting evasion. Here, we followed the hypothesis according to which metastasis as a whole implies the existence of metabolic sensors. Among others, mitochondria are singled out as a major source of superoxide that supports the metastatic phenotype. Molecularly, stressed cancer cells increase mitochondrial

SUBMITTER: Capeloa T 

PROVIDER: S-EPMC8946220 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature