Molecular Correlates of Venous Thromboembolism (VTE) in Ovarian Cancer.

ABSTRACT:

Background

The incidence of venous thromboembolism (VTE) in patients with ovarian cancer is higher than most solid tumors, ranging between 10-30%, and a diagnosis of VTE in this patient population is associated with worse oncologic outcomes. The tumor-specific molecular factors that may lead to the development of VTE are not well understood.

Objectives

The aim of this study was to identify molecular features present in ovarian tumors of patients with VTE compared to those without.

Methods

We performed a multiplatform omics analysis incorporating RNA and DNA sequencing, quantitative proteomics, as well as immune cell profiling of high-grade serous ovarian carcinoma (HGSC) samples from a cohort of 32 patients with or without VTE.

Results

Pathway analyses revealed

SUBMITTER: Glassman D 

PROVIDER: S-EPMC8946269 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature