A Novel Blood-Based microRNA Diagnostic Model with High Accuracy for Multi-Cancer Early Detection.

ABSTRACT: Early detection is critical to reduce cancer deaths as treating early stage cancers is more likely to be successful. However, patients with early stage diseases are often asymptomatic and thus less likely to be diagnosed. Here, we utilized four microarray datasets with a standardized platform to investigate comprehensive microRNA expression profiles from 7536 serum samples. A 4-miRNA diagnostic model was developed from the lung cancer training set (n = 416, 208 lung cancer patients and 208 non-cancer participants). The model showed 99% sensitivity and specificity in the lung cancer validation set (n = 3328, 1358 cancer patients and 1970 non-cancer participants); and the sensitivity remained to be >99% for patients with stage 1 disease. When applied to the additional combined dataset of 379

SUBMITTER: Zhang A 

PROVIDER: S-EPMC8946599 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature