DNA Methylation Malleability and Dysregulation in Cancer Progression: Understanding the Role of PARP1.

ABSTRACT: Mammalian genomic DNA methylation represents a key epigenetic modification and its dynamic regulation that fine-tunes the gene expression of multiple pathways during development. It maintains the gene expression of one generation of cells; particularly, the mitotic inheritance of gene-expression patterns makes it the key governing mechanism of epigenetic change to the next generation of cells. Convincing evidence from recent discoveries suggests that the dynamic regulation of DNA methylation is accomplished by the enzymatic action of TET dioxygenase, which oxidizes the methyl group of cytosine and activates transcription. As a result of aberrant DNA modifications, genes are improperly activated or inhibited in the inappropriate cellular context, contributing to a plethora of inheritable di

SUBMITTER: Srivastava R 

PROVIDER: S-EPMC8946700 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature