Breast Cancer Stem Cell Membrane Biomarkers: Therapy Targeting and Clinical Implications.

ABSTRACT: Breast cancer is the most common malignancy affecting women worldwide. Importantly, there have been significant improvements in prevention, early diagnosis, and treatment options, which resulted in a significant decrease in breast cancer mortality rates. Nevertheless, the high rates of incidence combined with therapy resistance result in cancer relapse and metastasis, which still contributes to unacceptably high mortality of breast cancer patients. In this context, a small subpopulation of highly tumourigenic cancer cells within the tumour bulk, commonly designated as breast cancer stem cells (BCSCs), have been suggested as key elements in therapy resistance, which are responsible for breast cancer relapses and distant metastasis. Thus, improvements in BCSC-targeting therapies are crucial

SUBMITTER: Conde I 

PROVIDER: S-EPMC8946706 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature