Impact of Cancer Stem Cells on Therapy Resistance in Gastric Cancer.

ABSTRACT: Gastric cancer (GC) is the fourth leading cause of cancer death worldwide, with an average 5-year survival rate of 32%, being of 6% for patients presenting distant metastasis. Despite the advances made in the treatment of GC, chemoresistance phenomena arise and promote recurrence, dissemination and dismal prognosis. In this context, gastric cancer stem cells (gCSCs), a small subset of cancer cells that exhibit unique characteristics, are decisive in therapy failure. gCSCs develop different protective mechanisms, such as the maintenance in a quiescent state as well as enhanced detoxification procedures and drug efflux activity, that make them insusceptible to current treatments. This, together with their self-renewal capacity and differentiation ability, represents major obstacles for the e

SUBMITTER: Otaegi-Ugartemendia M 

PROVIDER: S-EPMC8946717 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature