Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes.

ABSTRACT: The human skin and in particular its outermost layer, the epidermis, protects the body from potentially harmful substances, radiation as well as excessive water loss. However, the interference between the various stress responses of the epidermal keratinocytes, which often occur simultaneously, is largely unknown. The focus of this study was to investigate the interference between osmotic stress and DNA damage response. In addition to revealing the already well-described regulation of diverse gene sets, for example, cellular processes such as transcription, translation, and metabolic pathways (e.g., the KEGG citrate cycle and Reactome G2/M checkpoints), gene expression analysis of osmotically stressed keratinocytes revealed an influence on the transcription of genes also related to UV-indu

SUBMITTER: Hoen L 

PROVIDER: S-EPMC8946833 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature