Short-Term Functional and Morphological Changes in the Primary Cultures of Trigeminal Ganglion Cells.

ABSTRACT: Several studies have proved that glial cells, as well as neurons, play a role in pain pathophysiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to neuropathic pain. Likewise, some works have suggested that peripheral glial cells, particularly satellite glial cells (SGCs), and the crosstalk between these cells and the sensory neurons located in the peripheral ganglia, play a role in the phenomenon that leads to pain. Nonetheless, the study of SGCs may be challenging, as the validity of studying those cells in vitro is still controversial. In this study, a research protocol was developed to examine the potential use of primary mixed neuronal-glia cell cultures obtained from the trigeminal ganglion cells (TGCs) of neonate m

SUBMITTER: Verissimo CP 

PROVIDER: S-EPMC8946888 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature