TP53 Expression and Mutational Analysis in Hematological Malignancy in Jeddah, Saudi Arabia.

ABSTRACT: Tumor protein 53 (TP53) is a tumor-suppressor gene and plays an essential role in apoptosis, cell cycle arrest, genomic stability, and DNA repair. Although it is the most often mutated gene in human cancer, it has respectively low frequency in hematological malignancy but is significantly linked with complex karyotype, poor prognosis, and chemotherapeutic response. Nevertheless, the prevalence and prognostic role of TP53 mutations in hematological malignancy in Saudi patients are not well reported. We, therefore, aim to assess the frequency of TP53 mutations in hematological malignancies in Saudi Arabia. 20 different hematological malignancy samples were tested using fluorescence in situ hybridization (FISH) technique for TP53 deletion detection and next-generation sequencing (NGS) targete

SUBMITTER: Alkhatabi H 

PROVIDER: S-EPMC8946951 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature