Spin Lattice (T1) and Magnetization Transfer Saturation (MTsat) Imaging to Monitor Age-Related Differences in Skeletal Muscle Tissue.

ABSTRACT: The aim was to compare spin-lattice relaxation (T1) mapping from sequences with no fat suppression and three fat suppression methods and Magnetization Transfer Saturation (MTsat) mapping, to identify regional and age-related differences in calf muscle. These differences may be of clinical significance in age-related loss of muscle force. Ten young and seven senior subjects were imaged on a 3T MRI scanner using a 3D Fast Low Angle Shot sequence without and with different fat suppression and with MT saturation pulse. Bland-Altman plots were used to assess T1 maps using the fat unsuppressed sequence as the reference image. Age and regional differences in T1 and in MTsat were assessed using two-way factorial analyses of variance (ANOVAs) with Bonferroni-adjusted independent sample t-tests for

SUBMITTER: White JC 

PROVIDER: S-EPMC8947179 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature